SFB 80: RNA-DECO
Decorating RNA
for a purpose

Chemical modifications of RNAs allow the dynamic adaptation of organisms to respond to developmental or environmental changes.

funded by FWF — Der Wissenschaftsfonts

Mission

At SFB (F80), RNA-DECO 12 research groups in Austria comprising of biochemists, biologists and bioinformaticians jointly aim at understanding the impact of chemical modifications on:

Structure & Function of specific RNAs using different models.

RNA modifications affect

Participants

Scientific Advisory Board

News

2023-07-03

Branimir Ayvazov successfully completed an internship!

Branimir Ayvazov from Javier Martinez´s lab successfully completed an internship on “Characterization of the ANGEL2-PRMT1 protein complex”.

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2023-06-26

Renata Kleinova defended her Ph.D. thesis successfully!

Renata Kleinova from Michael Jantsch’s lab successfully defended her Ph.D. thesis on “The ADAR1 editome reveals drivers of editingspecificity for ADAR1-isoforms”.

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2023-05-12

Invited speaker Ramesh PILLAI

Ramesh PILLAI gave a talk at the 17th Microsymposium on RNA Biology Vienna.

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Publications

eIF4E1b is a non-canonical eIF4E required for maternal mRNA dormancy

Laura Lorenzo-Orts, Marcus Strobl, Benjamin Steinmetz, Friederike Leesch, Carina Pribitzer, Michael Schutzbier, Gerhard Dürnberger, Andrea Pauli

bioRxiv (2023)

Cleavage kinetics of human mitochondrial RNase P and contribution of its non-nuclease subunits

Elisa Vilardo, Roland Hartmann, Ursula Toth, Enxhi Hazisllari, Walter Rossmanith

Nucleic Acids Research accepted (2023) https://doi.org/10.1093/nar/gkad713

Evolutionary conservation of embryonic DNA methylome remodelling in distantly related teleost species

Samuel E. Ross, Javier Vázquez-Marín, Krista R.B. Gert, Álvaro González-Rajal, Marcel E. Dinger, Andrea Pauli, Juan Ramon Martínez-Morales, Ozren Bogdanovic

Nucleic Acids Research gkad695 (2023)

Open Positions

Ph.D. Position • open since July 10 2023

Ph.D. Position in RNA BIOLOGY

Medical University of Vienna
Center for Anatomy and Cell Biology
Dr. Matthias R. Schaefer
Schwarzspanierstrasse 17-I, 1090 Vienna, Austria
Email: matthias.schaefer@meduniwien.ac.at
Telephone: +43-1-40160-37702
Group Schaefer

Ph.D. Position in RNA BIOLOGY available

Title: SMALL RNA REGULATION OF METABOLIC ENZYMES

Pdh schaefer 2023

Transfer RNAs are indispensable for decoding mRNAs. Curiously, environmental stresses induce the fragmentation of some tRNAs. The resulting tRNA fragments impact cellular processes including survival, translation, intercellular communication, and the transfer of extra-chromosomal information between generations. However, the exact molecular mechanisms through which tRNA fragments affect cellular physiology are not known. Among the proteins that interact with specific tRNA fragments, we discovered various metabolic enzymes.

This Ph.D. project (embedded in an FWF-funded doc.fund, RNA@core) aims at deciphering the biological significance of these interactions using a combination of cell biology, biochemistry, epigenetics, and epitranscriptomics. The project can be started immediately.

Interested candidates should send a cover letter, CV, a short description of prior lab experience, and two contacts for reference to:

Dr. Matthias R. Schaefer
Medical University of Vienna, Center for Anatomy & Cell Biology
Schwarzspanierstrasse 17-I, 1090 Vienna, Austria
Email: matthias.schaefer@meduniwien.ac.at
Telephone: +43-1-40160-37702
Web: https://anatomie-zellbiologie.meduniwien.ac.at/group-schaefer

Ad for PhD Schaefer lab

Research technician position • open since November 08 2022

Research technician position in RNA modification biology

Medical University of Vienna
Center for Anatomy and Cell Biology
Elisa Vilardo, Ph.D.
Schwarzspanierstr. 17, A-1090 Vienna
Tel.: +43 1 40160 37724
E-mail: elisa.vilardo@meduniwien.ac.at
Group Vilardo

The group of Elisa Vilardo at the Center for Anatomy and Cell Biology is recruiting a Technical Assistant. The group works on the biology of tRNA modification, its impact on cell physiology and its implication in human disease. The projects involve the use of a diverse array of techniques, including tissue culture, molecular biology and biochemistry. We offer a young and international working environment within the frame of the Medical University of Vienna, located at the very heart of the city.
The ideal candidate will have a degree in biology, chemistry or related fields, and will be highly motivated to perform research in the life-sciences with the highest standards. Previous experience in cell and molecular biology is welcome, although further training will be provided in house as needed for the projects. The working language at the institute is English; knowledge of German will be of advantage.

The perspective start date is December 1st 2022.

If you are interested, please send a cover letter, CV, and two reference letters to elisa.vilardo@meduniwien.ac.at
Vilardo Tech ad

Master Thesis • open since November 08 2022

Master thesis in RNA modification biology

Medical University of Vienna
Center for Anatomy and Cell Biology
Elisa Vilardo, Ph.D.
Schwarzspanierstr. 17, A-1090 Vienna
Tel.: +43 1 40160 37724
E-mail: elisa.vilardo@meduniwien.ac.at
Group Vilardo

To date, more than 150 natural RNA modifications have been identified. However, the function and interplay among RNA modifications remains enigmatic. The Vilardo lab investigates RNA modifications in tRNAs, the key adaptor molecules between gene expression and protein translation. We use biochemistry, genome editing by Crispr/Cas9, and Next Generation Sequencing to investigate tRNA modifications and the enzymatic pathways responsible for modifications.
As part of the special research focus program RNA-Deco, we collaborate within a network of top RNA research laboratories across Austria.
If you are a highly motivated student in biology, biotechnology or similar subjects, and are interested to join our group at the Center for Anatomy and Cell Biology of the Medical University of Vienna, please send curriculum vitae, motivation letter and a recommendation letter to:
elisa.vilardo@meduniwien.ac.at
Vilardo Master ad