SFB 80: RNA-DECO
Decorating RNA
for a purpose

Ph.D. Position in RNA BIOLOGY available

Title: SMALL RNA REGULATION OF METABOLIC ENZYMES

Transfer RNAs are indispensable for decoding mRNAs. Curiously, environmental stresses induce the fragmentation of some tRNAs. The resulting tRNA fragments impact cellular processes including survival, translation, intercellular communication, and the transfer of extra-chromosomal information between generations. However, the exact molecular mechanisms through which tRNA fragments affect cellular physiology are not known. Among the proteins that interact with specific tRNA fragments, we discovered various metabolic enzymes.

This Ph.D. project (embedded in an FWF-funded doc.fund, RNA@core) aims at deciphering the biological significance of these interactions using a combination of cell biology, biochemistry, epigenetics, and epitranscriptomics. The project can be started immediately.

Interested candidates should send a cover letter, CV, a short description of prior lab experience, and two contacts for reference to:

Dr. Matthias R. Schaefer
Medical University of Vienna, Center for Anatomy & Cell Biology
Schwarzspanierstrasse 17-I, 1090 Vienna, Austria
Email: matthias.schaefer@meduniwien.ac.at
Telephone: +43-1-40160-37702
Web: https://anatomie-zellbiologie.meduniwien.ac.at/group-schaefer

Ad for PhD Schaefer lab

The group of Elisa Vilardo at the Center for Anatomy and Cell Biology is recruiting a Technical Assistant. The group works on the biology of tRNA modification, its impact on cell physiology and its implication in human disease. The projects involve the use of a diverse array of techniques, including tissue culture, molecular biology and biochemistry. We offer a young and international working environment within the frame of the Medical University of Vienna, located at the very heart of the city.
The ideal candidate will have a degree in biology, chemistry or related fields, and will be highly motivated to perform research in the life-sciences with the highest standards. Previous experience in cell and molecular biology is welcome, although further training will be provided in house as needed for the projects. The working language at the institute is English; knowledge of German will be of advantage.

The perspective start date is December 1st 2022.

If you are interested, please send a cover letter, CV, and two reference letters to elisa.vilardo@meduniwien.ac.at
Vilardo Tech ad

To date, more than 150 natural RNA modifications have been identified. However, the function and interplay among RNA modifications remains enigmatic. The Vilardo lab investigates RNA modifications in tRNAs, the key adaptor molecules between gene expression and protein translation. We use biochemistry, genome editing by Crispr/Cas9, and Next Generation Sequencing to investigate tRNA modifications and the enzymatic pathways responsible for modifications.
As part of the special research focus program RNA-Deco, we collaborate within a network of top RNA research laboratories across Austria.
If you are a highly motivated student in biology, biotechnology or similar subjects, and are interested to join our group at the Center for Anatomy and Cell Biology of the Medical University of Vienna, please send curriculum vitae, motivation letter and a recommendation letter to:
elisa.vilardo@meduniwien.ac.at
Vilardo Master ad